Mr Spin Activation Code
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The T cell activation mediator
*Mr Spin Activation Codes
*Mr Spin Activation Code Generator
CD3 is a member of the immunoglobulin superfamily and acts as a mediator of signal transduction. It is a multimeric protein composed of four distinct polypeptide chains (ε, γ, δ, ζ). Each of these chains contain immunoreceptor tyrosine activation motifs (ITAMS) which are required for initiation of signaling cascades, as they recruit protein tyrosine kinases, signaling intermediates and adapter molecules. CD3 is expressed by a high-percentage of circulating peripheral T cells forming a complex with the T cell receptor (TCR). As CD3 is present at all stages of T cell development, it is a highly effective T cell marker. Read our CD3 mini-review for detailed information on CD3 including its structure alongside that of the TCR, the genes involved in its expression, its function and the signal transduction pathways mediated by the CD3 complex.
For more information about T cells refer to the following resources available:
*T cell overview; including antibodies available to this important immune cell
*T cell receptor mini-review for detailed information on TCR activation, signaling, development and diversity
*Human T cell lineage posters
*Human T cell marker selection and expression guide
*Mouse T cell lineage posters
*Mouse T cell marker selection and expression guide
Here we look at anti-CD3 clones and their recommended applications.Anti-human CD3 clones
*Clone CD3-12, specifically recognizes a conserved epitope within the cytoplasmic sequence of the human CD3ε chain. The epitope on the epsilon polypeptide is conserved among many species resulting in antibody clone, CD3-12, having a very broad species cross reactivity for the CD3 marker. Applications for this antibody include flow cytometry, immunofluorescence/immunocytochemistry, immunohistochemistry – frozen, immunohistochemistry – paraffin sections and western blotting
*Clone MEM-57 recognizes an extracellular epitope of the human CD3 complex containing either δ-ε or γ-ε subunit complexes (Dave et al. 1998). Applications for this antibody include flow cytometry and immunoprecipitation
*Clone UCHT1 binds to a region in the ectodomain of human CD3ε and has been shown to bind to a discontinuous epitope near an acidic region of CD3ε opposite the dimer interface; as shown by crystallographic studies of the CD3ε/δ dimer complexed with a single chain UCHT1 antibody fragment (Arnett et al. 2004). Applications for this antibody include flow cytometry and immunohistochemistry – frozenAnti-mouse CD3 clonesMr Spin Activation Codes
*1,706 Likes, 65 Comments - Mitch Herbert (@mitchmherbert) on Instagram: “Excited to start this journey!
The T cell activation mediator
*Mr Spin Activation Codes
*Mr Spin Activation Code Generator
CD3 is a member of the immunoglobulin superfamily and acts as a mediator of signal transduction. It is a multimeric protein composed of four distinct polypeptide chains (ε, γ, δ, ζ). Each of these chains contain immunoreceptor tyrosine activation motifs (ITAMS) which are required for initiation of signaling cascades, as they recruit protein tyrosine kinases, signaling intermediates and adapter molecules. CD3 is expressed by a high-percentage of circulating peripheral T cells forming a complex with the T cell receptor (TCR). As CD3 is present at all stages of T cell development, it is a highly effective T cell marker. Read our CD3 mini-review for detailed information on CD3 including its structure alongside that of the TCR, the genes involved in its expression, its function and the signal transduction pathways mediated by the CD3 complex.
For more information about T cells refer to the following resources available:
*T cell overview; including antibodies available to this important immune cell
*T cell receptor mini-review for detailed information on TCR activation, signaling, development and diversity
*Human T cell lineage posters
*Human T cell marker selection and expression guide
*Mouse T cell lineage posters
*Mouse T cell marker selection and expression guide
Here we look at anti-CD3 clones and their recommended applications.Anti-human CD3 clones
*Clone CD3-12, specifically recognizes a conserved epitope within the cytoplasmic sequence of the human CD3ε chain. The epitope on the epsilon polypeptide is conserved among many species resulting in antibody clone, CD3-12, having a very broad species cross reactivity for the CD3 marker. Applications for this antibody include flow cytometry, immunofluorescence/immunocytochemistry, immunohistochemistry – frozen, immunohistochemistry – paraffin sections and western blotting
*Clone MEM-57 recognizes an extracellular epitope of the human CD3 complex containing either δ-ε or γ-ε subunit complexes (Dave et al. 1998). Applications for this antibody include flow cytometry and immunoprecipitation
*Clone UCHT1 binds to a region in the ectodomain of human CD3ε and has been shown to bind to a discontinuous epitope near an acidic region of CD3ε opposite the dimer interface; as shown by crystallographic studies of the CD3ε/δ dimer complexed with a single chain UCHT1 antibody fragment (Arnett et al. 2004). Applications for this antibody include flow cytometry and immunohistochemistry – frozenAnti-mouse CD3 clonesMr Spin Activation Codes
*1,706 Likes, 65 Comments - Mitch Herbert (@mitchmherbert) on Instagram: “Excited to start this journey!
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